Endometrial inflammation risk

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You are at increased risk of chronic endometritis (CE) or endometrial inflammation. Here is what you need to know.

One in three infertile women with RIF suffers from chronic endometritis. Endometrial health is of paramount importance for a successful pregnancy. A mild inflammatory reaction in the endometrial cavity is important for successful implantation but a strict balance between excess inflammation and reduced inflammation is equally important.

Too much inflammation or too little inflammation can lead to implantation failure or to recurrent miscarriage. Mild inflammation stimulates the conversion of blood NK cells to uterine NK cells (uNK cells). uNK cells are important for implantation because they activate trophoblastic embryonic cells to have a successful endometrial vascular invasion. This is the basis for healthy placenta formation.

Chronic endometritis is usually the result of a low-level bacterial infection and can be treated with oral antibiotics. The diagnosis of chronic endometritis does not require a positive bacterial or viral culture but an increased number of specific lymphocytes known as CD-138.

Inflammation of the endometrium could also be present without the presence of chronic endometritis when the endometrial immune profile (EIP), a test of the immune status of the endometrium assessed with an endometrial biopsy, is hyperactive. In this care, special anti-inflammatory supplements and medications can help but not antibiotics.

What should you do:

Speak to your doctor about ruling out chronic endometritis or excessive endometrial inflammation and if present, treat you with a proper treatment plan. We use antibiotics such as Doxycycline and Metronidazole or Cipro in various combinations according to the severity of the condition. Treatment of excessive non-bacterial endometrial inflammation is more complex and demands a highly customized mix of supplements and prescription medications. If you need such help, contact our office for a consultation.